PReS-FINAL-2102: Comparison of sensitivity and specificity of MAS and HLH diagnostic guidelines in 362 children with MAS complicating systemic JIA
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چکیده
PReS-FINAL-2102: Comparison of sensitivity and specificity of MAS and HLH diagnostic guidelines in 362 children with MAS complicating systemic JIA S Davì, F Minoia, AC Horne, E Demirkaya, N Ilowite, A Insalaco, M Ioseliani, M Jelusic-Drazic, MA Kapovic, O Kasapcopur, I Kone-Paut, L Lepore, C Li, S Magni-Manzoni, D Maritsi, D Mccurdy, R Merino, P Miettunen, N Ruperto, A Martini, RQ Cron, A Ravelli, International Investigator Consortium for MAS Diagnostic Criteria
منابع مشابه
Performance of current guidelines for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.
OBJECTIVE To compare the capacity of the 2004 diagnostic guidelines for hemophagocytic lymphohistiocytosis (HLH-2004) with the capacity of the preliminary diagnostic guidelines for systemic juvenile idiopathic arthritis (JIA)-associated macrophage activation syndrome (MAS) to discriminate MAS complicating systemic JIA from 2 potentially confusable conditions, represented by active systemic JIA ...
متن کاملSensitivity and specificity of current diagnostic guidelines in children with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
Background Early diagnosis of macrophage activations syndrome (MAS) in systemic juvenile idiopathic arthritis (sJIA) may be challenging because it may mimic the clinical features of the underlying disease or be confused with an infectious complication. However, the diagnostic value of the guidelines for hemophagocytic lymphohistiocytosis (HLH) (1) or sJIA-associated MAS (2) has seldom been exam...
متن کاملShould 2016 Criteria for Macrophage Activation Syndrome be applied in children with Kawasaki disease, as well as with systemic-onset juvenile idiopathic arthritis?
We read with deep interest the paper by Ravelli et al, who developed new criteria for the classification of macrophage activation syndrome (MAS) in patients with systemic-onset juvenile idiopathic arthritis (So-JIA). The hemophagocytic lymphohistiocytosis (HLH) diagnostic guidelines have been successfully used in the management of primary HLH, but there have been several limitations to their us...
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Introduction This is a case report of a 15 year old girl which presented with Pyrexia of Unknown Origin. She was initially treated for possible sepsis and then received treatment for Atypical Kawasaki’s. She was subsequently investigated for Haemophagocytic Lymphohistiocytosis (HLH). She was eventually diagnosed with Systemic Juvenile Idiopathic Arthritis (SoJIA) complicated with Macrophage Act...
متن کاملDistinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis.
OBJECTIVES To compare the pro-inflammatory cytokine profiles and the cytokine kinetics in patients with secondary macrophage activation syndrome (MAS) due to systemic-onset juvenile idiopathic arthritis (s-JIA) and in both active and inactive disease states of s-JIA (but no MAS), with those demonstrated in EBV-induced haemophagocytic lymphohistiocytosis (HLH) and Kawasaki disease (KD), and to i...
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